Influence of human genetic variation on nutritional requirements
by
Stover PJ.
Division of Nutritional Sciences,
Cornell University, Ithaca NY.
Am J Clin Nutr. 2006 Feb;83(2):436S-42S.

ABSTRACT

Genetic variation is known to affect food tolerances among human subpopulations and may also influence dietary requirements, giving rise to the new field of nutritional genomics and raising the possibility of individualizing nutritional intake for optimal health and disease prevention on the basis of an individual's genome. However, because gene-diet interactions are complex and poorly understood, the use of genomic knowledge to adjust population-based dietary recommendations is not without risk. Whereas current recommendations target most of the population to prevent nutritional deficiencies, inclusion of genomic criteria may indicate subpopulations that may incur differential benefit or risk from generalized recommendations and fortification policies. Current efforts to identify gene alleles that affect nutrient utilization have been enhanced by the identification of genetic variations that have expanded as a consequence of selection under extreme conditions. Identification of genetic variation that arose as a consequence of diet as a selective pressure helps to identify gene alleles that affect nutrient utilization. Understanding the molecular mechanisms underlying gene-nutrient interactions and their modification by genetic variation is expected to result in dietary recommendations and nutritional interventions that optimize individual health.

B6
SAMe
Folate
Inositol
Serotonin
Chromium
Tryptophan
Low-fat blues
Nutrigenomics
Iron deficiency
DL-phenylalanine
Calcium and mood
Vitamins and mood
Docosahexaenoic acid
Natural antidepressants
Catecholamine depletion
Bad moods and sick hearts
Ascorbic acid, mood, and sex

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