Rapid recovery from major depression using magnesium treatment
by
Eby GA, Eby KL.
George Eby Research, 14909-C Fitzhugh Road,
Austin, TX 78736, United States.
Med Hypotheses. 2006 Mar 14;

ABSTRACT

Major depression is a mood disorder characterized by a sense of inadequacy, despondency, decreased activity, pessimism, anhedonia and sadness where these symptoms severely disrupt and adversely affect the person's life, sometimes to such an extent that suicide is attempted or results. Antidepressant drugs are not always effective and some have been accused of causing an increased number of suicides particularly in young people. Magnesium deficiency is well known to produce neuropathologies. Only 16% of the magnesium found in whole wheat remains in refined flour, and magnesium has been removed from most drinking water supplies, setting a stage for human magnesium deficiency. Magnesium ions regulate calcium ion flow in neuronal calcium channels, helping to regulate neuronal nitric oxide production. In magnesium deficiency, neuronal requirements for magnesium may not be met, causing neuronal damage which could manifest as depression. Magnesium treatment is hypothesized to be effective in treating major depression resulting from intraneuronal magnesium deficits. These magnesium ion neuronal deficits may be induced by stress hormones, excessive dietary calcium as well as dietary deficiencies of magnesium. Case histories are presented showing rapid recovery (less than 7 days) from major depression using 125-300mg of magnesium (as glycinate and taurinate) with each meal and at bedtime. Magnesium was found usually effective for treatment of depression in general use. Related and accompanying mental illnesses in these case histories including traumatic brain injury, headache, suicidal ideation, anxiety, irritability, insomnia, postpartum depression, cocaine, alcohol and tobacco abuse, hypersensitivity to calcium, short-term memory loss and IQ loss were also benefited. Dietary deficiencies of magnesium, coupled with excess calcium and stress may cause many cases of other related symptoms including agitation, anxiety, irritability, confusion, asthenia, sleeplessness, headache, delirium, hallucinations and hyperexcitability, with each of these having been previously documented. The possibility that magnesium deficiency is the cause of most major depression and related mental health problems including IQ loss and addiction is enormously important to public health and is recommended for immediate further study. Fortifying refined grain and drinking water with biologically available magnesium to pre-twentieth century levels is recommended.

Magnesium
Cholesterol
Low-fat blues
Nutrigenomics
Iron deficiency
Vitamins and mood
Docosahexaenoic acid
Catecholamine depletion
Bad moods and sick hearts
Magnesium and Vitamin B6
Ascorbic acid, mood, and sex
Magnesium - acute antidepressant effect
Fasting/euphoria/ketone bodies/GABA(B) receptors

Refs
HOME
HedWeb
HerbWeb
BLTC Research
The Good Drug Guide
Paradise-Engineering
The Hedonistic Imperative
MDMA/Ecstasy: Utopian Pharmacology
Critique of Aldous Huxley's Brave New World